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Author: <span>Stewart Cromar</span>

Low serum cortisol predicts early death following Acute Myocardial Infarction

To determine whether low serum cortisol concentrations are associated with adverse prognosis in patients with acute myocardial infarction. Low serum cortisol concentrations have been associated with adverse prognosis in critical illness of diverse etiology. DESIGN: Nested case-control study. SETTING: Prospective cohort study of consecutive patients admitted with acute myocardial infarction …

Clinical and imaging associations of discrepancies between acute clinical stroke syndrome and infarct on brain imaging (’€œclinical-imaging dissociation’€)

Up to 20% of lacunar infarcts are clinically misdiagnosed as cortical infarcts and vice versa. The reasons for this discrepancy are unclear. We assessed clinical and imaging features which might explain this ‘clinical-imaging dissociation’ (C-ID). METHODS: Patients with an acute stroke syndrome (cortical or lacunar) underwent magnetic resonance imaging including …

Functional recovery following musculoskeletal injury in hospital workers

Background Hospital workers are at high risk of work-related musculoskeletal disorders (WRMSDs), but outcomes following such injuries have not been well studied longitudinally. Aims To ascertain functional recovery in hospital workers following incident WRMSDs and identify predictors of functional status. Methods Cases (incident WRMSD) and matched referents from two hospitals …

Counting cavitating lacunes underestimates the burden of lacunar infarction

On brain imaging, lacunes, or cerebrospinal fluid-containing cavities, are common and are often counted in epidemiological studies as old lacunar infarcts. The proportion of symptomatic lacunar infarcts that progress to lacunes is unknown. Noncavitating lacunar infarcts may continue to resemble white matter lesions. METHODS: We identified patients with acute lacunar …

The robust association between childhood physical abuse and heart disease in adulthood: Findings from a representative community sample

Objectives Although, the relationship between childhood physical abuse and adult heart disease has been documented, very few studies have controlled for many of the known risk factors for heart disease. The objective of the current study, therefore, was to investigate the association between childhood physical abuse and adult heart disease …

Immigrants’€™ duration of residence and adverse birth outcomes: A population-based study

Urquia ML, Frank JW, Glazier RH, Moineddin R, Matheson FI, Gagnon A.  Immigrants’€™ duration of residence and adverse birth outcomes: A population-based study. Br J Obst Gyn 2010; 117:591-601 DOI: 10.1111/j.1471-0528.2010.02523.x Mar 21, 2014

Differing Risk Factor Profiles of Ischemic Stroke Subtypes Evidence for a Distinct Lacunar Arteriopathy?

Background and Purpose’€” Differences in risk factor profiles between lacunar and other ischemic stroke subtypes may provide evidence for a distinct lacunar arteriopathy, but existing studies have limitations. We overcame these by pooling individual data on 2875 patients with first-ever ischemic stroke from 5 collaborating prospective stroke registers that used …

Antithrombotic drug use, cerebral microbleeds and intracerebral haemorrhage: a systematic review of published and unpublished studies

BACKGROUND AND PURPOSE: Cerebral microbleeds (MB) are potential risk factors for intracerebral hemorrhage (ICH), but it is unclear if they are a contraindication to using antithrombotic drugs. Insights could be gained by pooling data on MB frequency stratified by antithrombotic use in cohorts with ICH and ischemic stroke (IS)/transient ischemic …


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