Up to 20% of lacunar infarcts are clinically misdiagnosed as cortical infarcts and vice versa. The reasons for this discrepancy are unclear. We assessed clinical and imaging features which might explain this ‘clinical-imaging dissociation’ (C-ID). METHODS: Patients with an acute stroke syndrome (cortical or lacunar) underwent magnetic resonance imaging including …

Background Hospital workers are at high risk of work-related musculoskeletal disorders (WRMSDs), but outcomes following such injuries have not been well studied longitudinally. Aims To ascertain functional recovery in hospital workers following incident WRMSDs and identify predictors of functional status. Methods Cases (incident WRMSD) and matched referents from two hospitals …

On brain imaging, lacunes, or cerebrospinal fluid-containing cavities, are common and are often counted in epidemiological studies as old lacunar infarcts. The proportion of symptomatic lacunar infarcts that progress to lacunes is unknown. Noncavitating lacunar infarcts may continue to resemble white matter lesions. METHODS: We identified patients with acute lacunar …

Thomas McKeown was right in his primary claim that changing environments, rather than improved medical care, were responsible for much of the long wave of historical mortality decline in the UK since 1700. He was, however, apparently unaware that the beginning of the decline in infant and early-childhood mortality lagged …

Objectives Although, the relationship between childhood physical abuse and adult heart disease has been documented, very few studies have controlled for many of the known risk factors for heart disease. The objective of the current study, therefore, was to investigate the association between childhood physical abuse and adult heart disease …

Urquia ML, Frank JW, Glazier RH, Moineddin R, Matheson FI, Gagnon A.  Immigrants’€™ duration of residence and adverse birth outcomes: A population-based study. Br J Obst Gyn 2010; 117:591-601 DOI: 10.1111/j.1471-0528.2010.02523.x Mar 21, 2014

  A report by the Tobacco Advisory Group of the Royal College of Physicians. Mar 21, 2014

Background and Purpose’€” Differences in risk factor profiles between lacunar and other ischemic stroke subtypes may provide evidence for a distinct lacunar arteriopathy, but existing studies have limitations. We overcame these by pooling individual data on 2875 patients with first-ever ischemic stroke from 5 collaborating prospective stroke registers that used …

BACKGROUND AND PURPOSE: Cerebral microbleeds (MB) are potential risk factors for intracerebral hemorrhage (ICH), but it is unclear if they are a contraindication to using antithrombotic drugs. Insights could be gained by pooling data on MB frequency stratified by antithrombotic use in cohorts with ICH and ischemic stroke (IS)/transient ischemic …

Objectives Inequalities in health and educational outcomes in Scotland show a strong and persistent socioeconomic status gradient. Our aims were to provide policy-makers with a synthesis of international research evidence that assesses the effectiveness of early childhood interventions aimed at equitably promoting cognitive and social development and suggest potential areas …