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Sachet of doxycycline capsules

Stage 1: Understanding DoxyPEP

Understanding Biosocial Aspects of DoxyPEP in the UK is a qualitative research study run by Dr Chase Ledin. The study involves semi-structured interviews with doctors, nurses, health promotion specialists, microbiologists, and other allied healthcare professionals working in sexual health.


Background: Recent biomedical and clinical research has demonstrated good efficacy and safety of doxycycline use for preventing bacterial STIs (including chlamydia, gonorrhoea, and syphilis) amongst gay and bisexual men (GBMSM). This research situates DoxyPEP in relation to broader public health issues of antibiotic over-consumption, including sustainable antibiotic use and stewardship within population health.

Problem: Principally, public health researchers question if/whether increased use amongst GBMSM will have a disproportionate impact upon population health. However, recent social science scholarship has identified the need for more specific research about GBMSM-focussed health education tactics and stewardship strategies to avoid blaming discrete communities and making deterministic arguments against DoxyPEP use.


Research Focus: This research attends to the tensions between biological and social understandings of DoxyPEP, to uncover new ways of thinking about AMR stewardship in sexual health and medicine. The study is guided by two core questions:

  1. How and why do medical and healthcare practitioners understand the inclusion and implementation of DoxyPEP in sexual medicine? 
  2. How and why do practitioners define, negotiate, and/or contest the use of DoxyPEP within sexual communities?

Methods: The study uses semi-structured interviews with healthcare practitioners (n=16), including doctors, nurses, health promotion specialists, microbiologists, and allied health professionals.

Ethics & Funding: Ethical approval provided by Edinburgh Medical School Research Ethics Committee (25-EMREC-017). This study is funded by the Moray Endowment Fund (2025) and the Foundation for the Sociology of Health & Illness (2025).


Findings from the study are currently being written up. Stay tuned for more updates.


Stay tuned for more updates.

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